卢宇靖

作者: 时间:2019-02-27 点击数:

C1CB

卢宇靖
LU YUJING
教授
所属学院:
生物医药学院
导师类别:
博士生导师、硕士生导师
科研方向:
现主要研究方向为药物化学、有机化学和酶催化;主要从事抗耐药菌新靶点活性分子和特殊核酸结构荧光探针的设计、合成和作用分子机制研究,特别是天然药物的设计改造及其靶向活性的研究;此外,也从事药物合成及工艺路线研究、生物传感器及化学生物学的研究。    
联系方式:
luyj@gdut.edu.cn, 28069399@qq.com
博士招生学院:
生物医药学院
硕士招生学院:
生物医药学院


个人简述        
(限300字)        
卢宇靖博士,广东工业大学生物医药学院教授、博士生导师,任职于广东工业大学天然药物与绿色化学研究所、广东省药食同源综合利用与研究开发工程中心,Allan H. Conney新药研发联合实验室。2012年入选广东省高等学校千百十工程校级培养对象和广东工业大学培英育才人才计划培养对象。曾获广东省科学技术奖一等奖、教育部自然科学奖二等奖、广东省轻工业协会科技进步奖一等奖、广东工业大学先进科技工作者等荣誉称号。近年致力于药物化学、化学生物学和有机化学的相关研究工作,研究方向主要包括靶向新型药物靶点的小分子化合物设计与合成,重要特殊核酸结构新型荧光探针的设计合成与应用研究,特别是天然产物合成与结构改造及其生物学的应用研究。迄今为止在Journal of Medicinal Chemistry, Biosensors and BioelectronicsChem.Comm.ACS Chemical BiologyEuropean Journal of Medicinal ChemistrySensors & Actuators B等专业刊物上发表SCI论文近40篇;SCI论文总被引用次数超过900次,单篇引用超过200次;申请专利33项,授权12项。主持国家自然科学基金(两项)、广东省自然科学基(两项)、广州市产学研协调创新重大专项、教育部重点实验室开放基金等项目。


学科领域        
科学学位    
制药工程      
专业学位    
材料与化工(生物医药方向)   


教育背景        

2008-2010 香港理工大学应用生物与化学技术系、手性科学国家重点实验室(博士后)

2003-2008 中山大学药学院药物化学专业(硕博连读)(理学博士)

1999-2003 中山大学化工学院应用化学专业(理学学士)



工作经历        

2016-至今 广东工业大学 教授

2011-2016 广东工业大学 副教授

2010-2011广东工业大学 讲师



主要荣誉        

广东工业大学2011年优秀科技工作者,

第七批广东省千百十校级培养对象

2011年广东工业大学培英育才(科研类第二层次)培养对象,

2011年广东省科学技术奖励一等奖



主要论文        

1. Yuan-Yuan Zheng, Ruo-Lan Du, Sen-Yuan Cai, Zhi-Hua Liu, Zhi-Yuan Fang, Ting Liu, Lok-Yan So, Yu-Jing Lu*, Ning Sun and Kwok-Yin Wong. Study of Benzofuroquinolinium Derivatives as a New Class of Potent Antibacterial Agent and the Mode of Inhibition Targeting FtsZ. Frontiers in Microbiology, 2018, 9, 1937. (SCI 2区)

2. Wei Long, Yu-Jing Lu*, Kun Zhang, Xuan-He Huang, Jin-Qiang Hou, Sen-Yuan Cai, Ying Li, Xian Du, Leonard G. Luyt, Wing-Leung Wong, Cheuk-Fai Chow. Boosting the turn-on fluorescent signaling ability of thiazole orange dyes: The effectiveness of structural modification site and its unusual interaction behavior with nucleic acids. Dyes and Pigments 159 (2018) 449–456.(SCI 2区)

3. Cong Wang, Yu-Jing Lu,∗, Sen-Yuan Cai, Wei Long, Yuan-Yuan Zheng, Jing-Wen Lin, Yan Yan, Xuan-He Huang, Wing-Leung Wong, Kun Zhang, Cheuk-Fai Chow. Advancing small ligands targeting RNA for better binding affinity andspecificity: A study of structural influence through molecular design approach. Sensors and Actuators B: Chemical, 262, 2018, 386-394. (SCI 1区)

4. Yu-Jing Lu*, Xiao-Lu Guo, Miao-Han Xu, Wei-Wu Chen, Cheuk-Fai Chow. Selective visualization of DNA G-quadruplex structures in live cells with 1-methylquinolinium-based molecular probes: The importance of indolyl moiety position towards specificity. Dyes and Pigments, 143, 2017, 331-341. (SCI 2区)

5. Sun N, Du RL, Zheng YY, Huang BH, Guo Q, Zhang RF, Wong KY, Lu Yu-Jing*. Antibacterial activity of N-methylbenzofuro[3,2-b]quinoline and N-methylbenzoindolo[3,2-b]-quinoline derivatives and study of their mode of action. European Journal of Medicinal Chemistry. 135, 2017, 1-11. (SCI 2区)

6. Ning Sun, Cong Wang, Miao-Han Xu, Yu-Jing Lu*, Cheuk-Fai Chow. The interaction of a structural flexible small molecule with nucleic acid structures: Investigation of the origin of fluorescence signal discrimination in sensing and the utilization in live cell imaging. Sensors and Actuators B: Chemical, 250, 2017, 543-551. (SCI 2区)

7. Yu-Jing Lu*, Dong-Ping Hu, Kun Zhang, Wing-Leung Wong, Cheuk-Fai Chow. New pyridinium-based fluorescent dyes: A comparison of symmetry and side-group effects on G-Quadruplex DNA binding selectivity and application in live cell imaging. Biosensors and Bioelectronics, 81, 2016, 373-381. SCI 1区)

8. Yu-Jing Lu*, Qiang Deng, Jin-Qiang Hou, Dong-Ping Hu, Zheng-Ya Wang, Kun Zhang, Leonard G. Luyt, Wing-Leung Wong, and Cheuk-Fai Chow. Molecular Engineering of Thiazole Orange Dye: Change of Fluorescent Signaling from Universal to Specific upon Binding with Nucleic Acids in Bioassay. ACS Chemical Biology, 2016, 11, 1019-1029. (SCI 2区)

9. Yu-Jing Lu*, Qiang Deng, Dong-Ping Hu, Zheng-Ya Wang, Bao-Hua Huang, Zhi-Yun Du, Yan-Xiong Fang, Wing-Leung Wong, Kun Zhang and Cheuk-Fai Chow, A molecular fluorescent dye for specific staining and imaging of RNA in live cells: a novel ligand integration from classical thiazole orange and styryl compounds. Chem. Commun., 2015, 51, 15241-15244.(SCI 2区)

10. Yu-Jing Lu*, Dong-Ping Hu, Qiang Deng, Zheng-Ya Wang, Bao-Hua Huang, Yan-Xiong Fang, Kun Zhang and Wing-Leung Wong, Sensitive and selective detection of uracil-DNA glycosylase activity with a new pyridinium luminescent switch-on molecular probe. Analyst, 2015,140, 5998-6004.(SCI 2区)

11. Yu-Jing Lu*, Zheng-Ya Wang, Dong-Ping Hu, Qiang Deng, Bao-Hua Huang, Yan-Xiong Fang, Kun Zhang, Wing-Leung Wong, Cheuk-Fai Chow. Benzothiazole-substituted benzofuroquinolinium dyes as new fluorescent probes for G-quadruplex DNA. Dyes and Pigments, 2015, 122, 94–102.(SCI 2区)

12. Yu-Jing Lu, Wing-Leung Wong, Cheuk-Fai Chow, A surfactant-like ionic liquid with permanganate dissolved as a highly selective epoxidation system. Catalysis Communications, 2015, 69, 25–28.(SCI 3区)

13. Jiaqiang Liu, Chang Sun, Wenliang Ma, Yu-Jing Lu, Lin Yu, Kun Zhang and Huaqiang Zeng, A conformationally switchable fluorescent oligophenol foldamer for selective sensing of copper(II) ions. RSC Advances, 2014, 4, 54469-54473.

14. Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY. Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity. PLoS One. 2014, 13, 9(5): e97514.

15. Wang HQ, Li DL, Lu YJ, Cui XX, Zhou XF, Lin WP, Conney AH, Zhang K, Du ZY, Zheng X. Anticancer activity of Acanthopanax trifoliatus (L) Merr extracts is associated with inhibition of NF-kB activity and decreased Erk1/2 and Akt phosphorylation. Asian Pac J Cancer Prev. 2014; 15(21):9341-6.

16. Yue Wu, Li-Peng Zan, Xiao-Dong Wang, Yu-Jing Lu, Tian-Miao Ou, Jing Lin, Zhi-Shu Huang, Lian-Quan Gu, Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives. Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840, 2970–2977. (SCIⅡ区)

17. Pan-Pan Wu , Kun Zhang, Yu-Jing Lu, Ping He, Su-Qing Zhao, In vitro and in vivo evaluation of the antidiabetic activity of ursolic acid derivatives. European Journal of Medicinal Chemistry, 2014, 80, 502-508.

18. Chang Sun, Ying Liu, Jiaqiang Liu, Yu-Jing Lu, Lin Yu, Kun Zhang, and Huaqiang Zeng, Computational Insights into Processes Underlying the Amine-Induced Fluorescence Quenching of a Stimuli-Responsive Phenol-Based Hexameric Foldamer Host. J. Org. Chem., 2014, 79, 2963–2973.(SCIⅡ区)

19. Bin Qiu, Ya-shan zhang, Yi-bing Lin, Yu-Jing Lu, Zhen-yu Lin, Kwok-Yin Wong, Guo-nan Chen, A novel fluorescent biosensor for detection of target DNA fragment from the transgene cauliflower mosaic virus 35S promoter. Biosensors and Bioelectronics, Volume 41, 15 March 2013, Pages 168–171. (SCI 1区)

20. Yi-Yong Yan, Jia-Heng Tan, Yu-Jing Lu, Siu-Cheong Yan, Kwok-Yin Wong, Ding Li, Lian-Quan Gu, Zhi-Shu Huang, G-Quadruplex conformational change driven by pH variation with potential application as a nanoswitch. BBA - General Subjects, 2013, 1830, 4935-4942. (SCIⅡ区)

21. Yu-Jing Lu, Na Ma, Yu-jun Li, Zhen-yu Lin, Bin Qiu, Guo-nan Chen, Kwok-Yin Wong. Styryl quinolinium/G-quadruplex complex for dual-channel fluorescent sensing of Ag+ and cysteine. Sensors and Actuators B, 2012, 173, 295– 299.(SCIⅡ区)

22. Yu-Jing Lu, Siu-Cheong Yan, Fung-Yi Chan, Lan Zou, Wai-Hong Chung, Wing-Leung Wong, Bin Qiu, Ning Sun, Pak-Ho Chan, Zhi-Shu Huang, Lian-Quan Gu, and Kwok-Yin Wong. Benzothiazole-substituted benzofuroquinolinium dye: a selective switch-on fluorescent probe for G-quadruplex. Chemical Communication. 2011, 47, 4971-4973.(SCIⅡ区)

23. Yu-Jing Lu, Tian-Miao Ou, Jia-Heng Tan, Jin-Qiang Hou, Wei-Yan Shao, Dan Peng, Ning Sun, Xiao-Dong Wang, Wei-Bin Wu, Xian-Zhang Bu, Zhi-Shu Huang, Dik-Lung Ma, Kwok-Yin Wong, Lian-Quan Gu. 5-N-Methylated Quindoline Derivatives as Telomeric G-Quadruplex Stabilizing Ligands: Effects of 5-N Positive Charge on Quadruplex Binding Affinity and Cell Proliferation. Journal of Medicinal Chemistry, 2008, 51, 6381-6392.(SCIⅡ区)

24. Tian-Miao Ou, Jing Lin, Yu-Jing Lu, Jin-Qiang Hou, Jia-Heng Tan, Shu-Han Chen, Zeng Li, Yan-Ping Li, Ding Li, Lian-Quan Gu, Zhi-Shu Huang, Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction with c-myc Promoter G-Quadruplex, Journal of Medicinal Chemistry, 2011, 54, 5671–5679.(SCIⅡ区)

25. Bin Qiu, Zhen-Zhu Zheng, Yu-Jing Lu, Zhen-Yu Lin, Kwok-Yin Wong, Guo-Nan Chen, G-quadruplex DNAzyme as the turn on switch for fluorimetric detection of genetically modified organisms, Chemical Communications, 2011, 47, 1437-1439.(SCIⅡ区)

26. Xiao-Dong Wang, Tian-Miao Ou, Yu-Jing Lu, Zeng Li, Zheng Xu, Lian-Quan Gu, Zhi-Shu Huang. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. Journal of Medicinal Chemistry, 2010, 53, 4390-4398.(SCIⅡ区)

27. Tian-Miao Ou, Yu-Jing Lu,Chi Zhang, Zhi-Shu Huang, Xiao-Dong Wang, Jia-Heng Tan, Yuan Chen, Dik-Lung Ma, Kwok-Yin Wong, Johnny Cheuk-On Tang, Albert Sun-Chi Chan , Lian-Quan Gu. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. Journal of Medicinal Chemistry, 2007, 50, 1465-1474. (Contributed equally with 1st author)(SCIⅡ区)

28. Jia-Heng Tan, Tian-Miao Ou, Jin-Qiang Hou, Yu-Jing Lu, Shi-Liang Huang, Hai-Bin Luo, Jian-Yong Wu, Zhi-Shu Huang, Kwok-Yin Wong, Lian-Quan Gu, Isaindigotone Derivatives: A New Class of Highly Selective Ligands for Telomeric G-Quadruplex DNA, Journal of Medicinal Chemistry, 2009, 52, 2825–2835.(SCIⅡ区)

29. Yu-Jing Lu, Ning Sun, Zhi Shu Huang, Lian Quan Gu. A rapid and efficient synthesis of indoloquinolinone and its analogues under microwave irradiation. Chinese Chemical Letters, 2008, 19, 518-520.

30. Tian-Miao Ou, Yu-Jing Lu, Jia-Heng Tan, Zhi-Shu Huang, Kwok-Yin Wong, Lian-Quan Gu. G-quadruplexes: targets in anticancer drug design. ChemMedChem, 2008, 3,690-713.

31. Qi-Biao Su , Fan He , Xue-Ding Wang , Su Guan , Zhi-Yong Xie , Lai-You Wang , Yu-Jing Lu , Lian-Quan Gu , Zhi-Shu Huang , Xiao Chen , Min Huang , Shu-Feng Zhou. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat. Investigational New Drugs. 2008, 26, 119-137.

32. Chi Zhang, Wei-Bin Wu, Yu-Jing Lu, Lian-Quan Gu, Zhi-Shu Huang. Molecular modeling studies of interactions between quindoline derivatives and G-quadruplex. Acta Chimica Sinica. 2008, 66, 953-958.

33. Yan Ma, Tian-Miao Ou, Jin-Qiang Hou, Yu-Jing Lu, Jia-Heng Tan, Lian-Quan Gu, Zhi-Shu Huang. 9-N-substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc. Bioorganic & Medicinal Chemistry, 2008, 16, 7582-7591.

34. Jia-Heng Tan, Yu-Jing Lu, Zhi-Shu Huang, Lian-Quan Gu and Jian-Yong Wu. Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin. European Journal of Medicinal Chemistry, 2007, 42, 1169-1175.

35. Wan-Jin Zhang, Tian-Miao Ou, Yu-Jing Lu, Ying-Yu Huang, Wei-Bin Wu, Zhi-Shu Huang, Jin-Lin Zhou, Kwok-Yin Wong, and Lian-Quan Gu. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA. Bioorganic & Medicinal Chemistry, 2007, 15, 5493-5501.

36. Qi-Biao Su , Fan He , Su Guan , Yu-Jing Lu , Lian-Quan Gu , Zhi-Shu Huang , Xiao Chen , Min Huang , Chun-Guang Li , Balram Chowbay , Shu-Feng Zhou. High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: Application to an enzyme kinetic study in rat liver microsomes. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2007, 854, 332-337.

37. J-M Zhou, X-F Zhu, Y-J Lu, R Deng, Z-S Huang, Y-P Mei, Y Wang, W-L Huang, Z-C Liu, L-Q Gu and Y-X Zeng. Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. Oncogene, 2006, 25, 503-511.

38. Jin-Lin Zhou, Yu-Jing Lu, Tian-Miao Ou, Jun-Min Zhou, Zhi-Shu Huang, Xiao-Feng Zhu, Cui-Juan Du, Xian-Zhang Bu, Lin Ma, Lian-Quan Gu, Yue-Ming Li, and Albert Sun-Chi Chan. Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase. Journal of Medicinal Chemistry, 2005, 48, 7315-7321.(SCIⅡ区)








知识产权        

1、 黄玄贺 卢宇靖 蔡森源 李莹 龙威 张焜 黄宝华,一种曲美他嗪半抗原、人工抗原及其制备方法和应用 - 201810632217.2;

2、黄玄贺 卢宇靖 蔡森源 李莹 龙威 黄宝华 张焜,西地那非半抗原、人工抗原及其制备方法 - 201810246409.X;

3卢宇靖 李莹 蔡森源 郑园园 龙威 王聪,吲哚乙烯取代喹啉衍生物在制备抗耐药菌药物中的应用 - 201810463223.X;

4、蔡森源 卢宇靖 黄玄贺 李莹 龙威 黄宝华 张焜,西地那非半抗原、人工抗原及其制备方法 - 201810247752.6;

5、龙威 张焜 卢宇靖 李莹 杜现 王聪 蔡森源 郑园园 林丹敏, 核酸染料化合物及其制备方法和应用 201810042612.5;

6、龙威 张焜 卢宇靖 王聪 蔡森源 郑园园 林丹敏,化合物、其制备方法、荧光染料和荧光探针 - 201710771689.1;

7卢宇靖 张焜 黄宝华 杜志云 庄子翀 雷琳 付成杰 胡冬萍 邓强 王郑亚。常山碱衍生物及其在制备抗耐药菌药物中的应用 - 201410168506.3;103980251B,授权

8、张焜 付成杰 卢宇靖 邓强 王郑亚 胡冬萍 周小芬 杜志云 郑希 黄宝华 方岩雄。一种苯并呋喃喹啉化合物作为双功能pH探针的应用 - 201310536862.1;103575714B,授权

9卢宇靖 张焜 A•H•康尼 郑希 张瑞瑞 杜志云 张瑞芳 付成杰 周代营 王华倩 方岩雄 赵肃清 黄宝华。一种苯胺基取代甲基苯并呋喃喹啉衍生物及其制备方法和应用。申请号:201210117361.5,授权

10、黄志纾 卢宇靖 李增 古练权 谭家恒。一种双脂肪氨基取代吲哚喹啉衍生物及其制备方法和制备抗肿瘤药物中的应用。申请号:201110093613.0;

11、黄志纾,古练权,卢宇靖,欧田苗。 一种脂肪氨基取代甲基吲哚喹啉衍生物及其制备方法和制备抗肿瘤药物中的应用。 中国专利申请号:200810027094.6 ,授权



科研项目        

1)国家自然科学基金面上基金:耐药菌特异性蛋白FtsZ新型抑制剂的发现与作用机理研究[65万,2015.01-2018.12,主持]

2)广东省农业厅农业科技创新项目:柑橘功能因子的生物酶法制备及其产业化应用关键技术研发,(2018LM2175[50万,2019.01.01-2019.12.31,主持]

3)国家自然科学基金青年基金:新型荧光探针MQ-TO 细胞内实时示踪G-四链体DNA 行为的研究(21102021[25万,2012.01-2014.12,主持]

4)广州市产学研协调创新重大专项:基于免疫胶体金技术的非法添加快筛试剂盒研发[100万(到校30万),2015-2017,合作单位主持]

5)广东省自然科学基金博士启动基金:噻唑取代吲哚喹啉荧光示踪细胞内核酸G-四链体结构的研究(S2011040004201[3万,2011.10-2013.10,主持]

6)广东工业大学培英育才(科研类)人才项目:基于天然产物开发抗肿瘤药物的基础研究[40万,2012.5-2016.5,主持]

7)广东省科技计划攻关项目:抗球虫药常山酮全合成新工艺的开发研究(No.2012B020306007 [8万,2012-2014,排名第二]



教学活动        

主要从事制药工程相关的专业课程,如《专业英语》、《药物合成反应》、《专业实验》等课程的理论教学及实践教学。



我的团队        

本团队隶属于广工大绿色化学与天然药物研究所广工大Allan Conney抗肿瘤药物实验室以及广东省药食同源植物资源开发与利用工程中心;主要合作者包括:张焜教授、方岩雄教授、赵肃清教授、杜志云教授、郑希教授、黄宝华教授等。


地址:广州市番禺区广州大学城外环西路100号广东工业大学行政楼325    邮编:510006

电话:020-39322722    邮箱:yzb@gdut.edu.cn