徐凯林 副教授
导师类型：硕士生导师
所属学院：生物医药学院
办公地点：广东工业大学科技南楼生物医药学院205-1室；
广东工业大学工学二号馆国家重点实验室305-1室
E-mail：xukailin@gdut.edu.cn
科研方向：
1、药物晶体学，包括药物结构优化及结晶过程研究，药物同质多晶/无定型/共晶/盐及其药学性质研究等，重点在糖尿病药物研究；
2、新型药剂学，包括药物制剂新技术、药物缓控释制剂、新型抗癌组合疗法多功能复合纳米材料的设计及应用；
3、新一代人工智能驱动的药物研发和生产（联合本校国家重点实验室团队指导），包括药物研发、工艺规划、制药工厂设计与绿色生产运行优化中的垂域大模型、生成式人工智能（GenAI）、物理介导Agentic AI以及可解释物理信息神经网络（PINN）等应用基础研究。
个人简介：
徐凯林，博士/副教授/硕士生导师，香港大学访问学者，广东工业大学“青年百人计划”A层次引进人才，生物医药学院制药工程系教师，学校“十佳授课教师”。目前研究主要集中在药物晶体学、新型药剂学、新一代人工智能驱动的药物研发与生产等领域；重点在糖尿病药物的研究。先后主持国家自然科学基金青年基金1项、广东省自然科学基金面上项目1项、广州市基础与应用基础研究项目1项、广东工业大学“青年百人计划”科研项目1项，参与国家重点研发计划项目2项。已在包括International Journal of Pharmaceutics, ChemComm, Chemical Engineering Science, Renewable & Sustainable Energy Reviews, CrystEngComm, Journal of Cleaner Production等SCI期刊上发表学术论文50余篇，其中第一作者或通讯作者发表SCI论文20余篇，入选ESI 1%高被引论文4篇；授权美国发明专利1项、中国发明专利2项，申请中国及美国专利多项；担任International Journal of Pharmaceutics, International Journal of Production Research，IEEE Trans.等国际期刊审稿专家。
教育及工作经历：
2011.09-2017.06：四川大学，制药工程专业，硕士、博士；
2018.03-2019.03：香港大学，李嘉诚医学院，访问学者；
2017.07-至今：广东工业大学，讲师→副教授。
科研项目：
1. 国家自然科学基金青年基金：蛋白质介导分子组装的药物晶型调控研究， 30万元，主持。
2. 国家重点研发计划课题：高端装备数字化测评与现场在线认可技术研究，146万元，第2成员。
3. 国家重点研发计划任务：产品研发过程多层级数字孪生构建理论与应用技术，60万元，第2成员。
4. 广东省自然科学基金面上项目：基于蛋白质诱导分子构象变化的优势晶型设计/控制策略建立及机理研究，10万元，主持。
5. 广州市基础与应用基础研究项目：HSA/DPP-4/PEP驱动药物分子组装诱导同质多晶的研究，5万元，主持。
6. 广东工业大学“青年百人计划”项目：药物同质多晶现象研究，10万元，主持。
7. 广东省药品监督管理局科技项目引导扶持专项：中药有害物质免疫检测方法及降解技术研究，30万元，第4成员。
主要论文：
1. Jierui Huo, Shujin Liao, Xinyu Liu, Jianping Wang, Liyin Liang, Qiaomei Sun, Jie Bai, Suqing Zhao, Kailin Xu*. Human serum albumin–aripiprazole monohydrate interactions promote microcrystal formation of aripiprazole: mechanistic evidence for protein-mediated suppression of crystal growth. Chemical Engineering Science, 2026, 327, 123650.
2. Kailin Xu, Jianping Wang, Jierui Huo, Shujin Liao, Jie Bai, Xiangguang Li, Jie Zheng, Qiaomei Sun, Suqing Zhao*. Characterization and formation of diverse solid forms of trelagliptin including a novel dihydrate and two co-amorphous forms. Journal of Molecular Structure, 2026, 1353 (1), 144500.
3. Jiewu Leng, Jiwei Guo, Dewen Wang, Yuanwei Zhong, Chunyang Yu, Zhipeng Ye, Kailin Xu*, Sihan Huang, and Qiang Liu. Blockchain-of-Things-Based Edge Learning Contracts for Federated Predictive Maintenance Toward Resilient Manufacturing. IEEE Transactions on Computational Social Systems, 2024, 11 (6), 7990-8004.
4. Linjin Yu, Chuyan Chao, Qinglan Li, Songling Ye, Jiasen Lin, Shuling Zhong, Qiancheng Xuan, Kailin Xu*, Suqing Zhao*. A co-encapsulation of coenzyme Q10 and curcumin in liposomes coated with chitosan (Q10-Cur-Lip-Chi) with enhanced solubility and stability for good release performance and antioxidative activity. Current Drug Delivery, 2023, 20 (9), 1391-1403.
5. Jiewu Leng, Yuanwei Zhong, Zisheng Lin, Kailin Xu *, Dimitris Mourtzis, Zhou Xueliang, Zheng Pai, Liu Qiang *, J. Leon Zhao, Shen Weiming. Towards resilience in Industry 5.0: A decentralized autonomous manufacturing paradigm. Journal of Manufacturing Systems, 2023, 71, 95-114. (高被引论文)
6. Qinglan Li, Li Ji, Beibei Jiang, Xiangguang Li, Zhaoji Lv, Jinpo Xie, Siping Chen, Kailin Xu*, Yingwei Yang and Suqing Zhao*. Pillararene-functionalized rhodium nanoparticles for efficient catalytic reduction and photothermal sterilization. Chemical Communications, 2022, 58, 13079–13082.
7. Kailin Xu, Bai Jie, Qing-Lan Li, and Suqing Zhao. Polymorphs and amorphous state of glipizide: preparation and solid-state transformations. Journal of Pharmaceutical Sciences, 2021, 110 (4), 1718-1726.
8. Kailin Xu, Menglin Qian, Jiewu Leng, Jie Bai, Qinglan Li, Zihong Liu, Shijuan Zhong and Suqing Zhao. Direct salinization of trelagliptin from solid forms by mechanochemistry and its mechanism of salts forming . CrystEngComm, 2020, 22, 8256–8265.
9. Jiewu Leng, Guolei Ruan, Pingyu Jiang, Kailin Xu*, Qiang Liu, Xueliang Zhou, and Chao Liu. Blockchain-empowered sustainable manufacturing and product lifecycle management in Industry 4.0: A survey. Renewable & Sustainable Energy Reviews. 2020, 132, 110112. (IF:16.8, ESI 1% 高被引论文)
10. Jiewu Leng, Pingyu Jiang, Kailin Xu*, Qiang Liu, J. Leon Zhao, Yiyang Bian, Rui Shi. Makerchain: A blockchain with chemical signature for self-organizing process in social manufacturing. Journal of Cleaner Production, 2019, 234, 767-778.
11. Xu Kailin, Zheng Shoujun, Zhai Yuanming, et al. Two solid forms of tauroursodeoxycholic acid and the effects of milling and storage temperature on solid-state transformations . International Journal of Pharmaceutics, 2015, 486(1), 185-194.
12. Xu Kailin, Xiong Xinnuo, Li Shanshan, et al. New polymorph of glipizide with enhanced properties obtained using environmentally friendly methods . CrystEngComm, 2016, 18, 4508–4512.
13. Xu Kailin, Liang Bin, Li Yanfang, et al. Injection-ultrasound-assisted emulsification microextraction based on using low-density organic solvent followed by high-performance liquid chromatography for the determination of pyrethroids in water samples. Analyst, 2013, 138(4), 1262-1270.
14. Xu Kailin, Xiong Xinnuo, Zhai Yuanming, et al. Effect of milling conditions on solid-state amorphization of glipizide, and characterization and stability of solid forms . Journal of Pharmaceutical and Biomedical Analysis, 2016, 129: 367-377.
15. Xu Kailin, Zheng Shoujun, Guo Liuqi, et al. Four solid forms of tauroursodeoxycholic acid and solid-state transformations: effects of temperature and milling . RSC Advances, 2015, 5(117), 96392-96403.
16. Xu Kailin, Xiong Xinnuo, Guo Liuqi, et al. An Investigation into the Polymorphism and Crystallization of Levetiracetam and the Stability of its Solid Form . Journal of Pharmaceutical Sciences, 2015, 104(12), 4123-4131.
17. Xu Kailin, Liang Bin, Wu Xiaoqing, et al. X-ray powder diffraction data for levetiracetam . Powder Diffraction, 2014, 29(01), 51-52.
18. Xiao Yin, Xu Kailin, Wang Qing, et al. Synthesis, structure, and calf-thymus DNA binding of ternary fleroxacin–Cu (II) complexes. RSC Advances, 2016, 6(83): 80286-80295.
19. Li Zhenzhen, Xu Kailin, Liang Bin, et al. Determination of trace tetracyclines in surface water by aluminum hydroxide coprecipitation coupled with high-performance liquid chromatography . Analytical Methods, 2013, 5(14), 3516-3522.
20. Cheng Yuan, Xu Kailin, Li Hui, et al. Preparation of Urea-Imprinted Cross-Linked Chitosan and Its Adsorption Behavior . Analytical Letters, 2014, 47(6), 1063-1078.
21. Li Xiangling, Xu Kailin, Li Hui, et al. Qualitative analysis of chiral alanine by UV-visible-shortwave near infrared diffuse reflectance spectroscopy combined with chemometrics . RSC Advances, 2016, 6(10), 8395-8405.
22. Huayu Zou, Kailin Xu, Yuyan Feng, Bing Liang. Application of first order derivative UV spectrophotometry coupled with H-point standard addition to the simultaneous determination of melamine and dicyandiamide in milk [J]. Food analytical methods, 2015, 8(3), 740-748.
23. Xinnuo Xiong, Kailin Xu, Shanshan Li, Peixiao Tang, Ying Xiao, Hui Li. Solid-state amorphization of rebamipide and investigation on solubility and stability of the amorphous form [J], Drug Development and Industrial Pharmacy, 2016, 1-10.
24. Xinnuo Xiong, Kailin Xu, Qiaohong Du, Xia Zeng, Ying Xiao, Yanmei Huang, Hui Li. Effects of temperature and solvent on the solid-state transformations of pranlukast during mechanical Milling [J], Journal of Pharmaceutical Sciences, 2017, doi 10.1016/j.xphs.2017.02.020.
25. Liuqi Guo, Kailin Xu, Xiaoli Ma, Shanshan Li, Hui Li. X-ray powder diffraction data for niclosamide [J], Powder Diffraction, 2015, 30, 375-377.
26. Shoujun Zheng, Kailin Xu, Qing Wang, Xiaolin Tang, Yanmei Huang, Peixiao Tang, Lijuan Chen, Hui Li. X-ray powder diffraction data for 2-[((3R)-5-oxo-4-phenyltetrahy drofuran-3-yl)methyl]isoindoline-1,3-dione [J], Powder Diffraction, 2016, 31, 155-158.
主要专利：
1. Kailin XU, Jierui HUO, Jianping WANG, Suqing ZHAO. Novel crystal form of trelagliptin and preparation method. US18/522,287, 2025[美国专利授权].
2. Kailin XU, Jierui HUO, Jianping WANG, Jie Bai, Suqing ZHAO. A method for simultaneously regulating crystal forms and crystal habits of aripiprazole drug and aripiprazole crystal forms. US18/954,397. 2025;[美国专利].
3. Kailin XU, Jianping WANG, Jierui HUO, Jie Bai, Suqing ZHAO. Key amino acids based on protein-drug interactions induce new crystal forms of trelagliptin and preparation methods. US19/021,272. 2025;[美国专利].
4. 徐凯林;穆双全;赵肃清;李清兰;钟诗娟. 中国专利. ZL 2022 1 1577018.9. 曲格列汀新晶型F及其制备方法. 2024[授权].
5. 徐凯林;陈晓珊;何燕;赵肃清;周丽华;巫晓姗;刘思. ZL 201910754899.9 一种结晶态曲格列汀及其制备方法和应用、曲格列汀琥珀酸盐晶体及其制备方法. 2021 [授权].
6. 徐凯林,霍杰瑞,王建平,白杰,赵肃清. 中国发明专利. CN202411432707.X一种同时调控阿立哌唑新晶型和晶习的方法及其新晶型. 2024.
7. 徐凯林,王建平,霍杰瑞,白杰,赵肃清,刘新宇,梁立尹,廖书进. 中国发明专利. CN2024118574517. 基于蛋白-药物相互作用的关键氨基酸诱导曲格列汀新晶型及其制备方法. 2024.
8. 徐凯林,刘新宇,梁立尹,廖书进,赵肃清. 中国发明专利. CN 202511996768.3. 一种尼莫地平晶型及其诱导方法. 2025.
9. 徐凯林,梁立尹,刘新宇,廖书进,赵肃清. 中国发明专利. CN 2025119976771. 布地奈德新晶型及其制备方法. 2025.
曾获荣誉：
1. 广东工业大学 第八届 青年教师教学竞赛 “十佳授课教师”
2. 广东工业大学 生物医药学院第一届青年教师教学竞赛 一等奖
3. 第十二届全国大学生制药工程设计竞赛 二等奖 第一指导老师
4. 第十一届全国大学生制药工程设计竞赛 二等奖 第一指导老师
5. 2022-2023年度 广东工业大学 年度考核优秀奖
6. 2022-2023学年 广东工业大学 教学优秀奖 二等奖
7. 2021-2022学年 广东工业大学 教学优秀奖 二等奖
教学活动：
主要从事制药工程专业相关的课程，如《药物智造与评价》、《人工智能与生物医药导论》、《制药过程安全与环保》、《工业药剂学》、《药物合成反应》、《晶体世界与生活》等课程的理论教学及实践教学。
